Bioreactor system Esco TideXcell ®

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The pilot-scale Esco TideXcell® bioreactor system is also packed with desirable and advanced features such as the ability to measure pH and DO (Dissolved Oxygen), Siemens HMIs or PLC-based monitoring and control systems, pipelines Compressed air comes with dual HEPA and VOC (volatile organic chemicals) filters as well as other accessories.

I. Specification Esco TideXcell ® cell culture system

Tidal movements in the Esco TideXcell ® bioreactor:

[video width="600" height="400" mp4="https://gmga.vn/wp-content/uploads/2021/11/Hệ-thống-nuôi-cấy-tế-bào-Esco-TideXcell-®_01.mp4" autoplay="true"][/video]

Advantages of Esco TideXcell ®:

Adhesive cell scale for packing bed volumes up to 5,000L (bioequivalent of 50,000 L in suspension)
100% media exchange system ideal for continuous bioprocessing
Separation of substrate and mixing vessel -implements dual temperature control to produce higher virus titers
Integrated weighing platform and in-house mixer
PLC-based monitoring Esco TideXcell® bioreactor system - with simple, intuitive touch screen running on Wonderware SCADA
Can be connected to SCADA system by DeltaV or Pcs7 . controller
Dual redundancy - for critical components such as PLCs and pumps provided
Delivers massive downscaling - and reduces costs by saving vehicles, labor, space, utility, and most importantly, eliminating cross-contamination
Isolation ability.
cGMP Standard Reference
PAT / IPQC.

Esco TideXcell ® - Applications:

Culture of anchorage-dependent cells with BioNOC™
Train series cell
Vaccine production
Production of recombinant proteins and monoclonal antibodies
Biosimilars and biobetters
Convert from 2D system to closed 3D system
Continuous biological treatment
Production of wild virus
Cell therapy
Biologic drugs for tropical diseases.

II. Highlights of Esco TideXcell ® pilot bioreactor system

Bioreactor system Esco TideXcell ®

Homogeneous seed:

TideXcell ® Matrix Bed is designed to cut the area into small pieces and force the cells to flow in a radial direction instead of a vertical direction. The gradient effect in the seeding stage can be minimized.
A matrix cassette packed with 3D-configured carriers for optimal cell growth. Paper trays are stacked inside the matrix flask (2 L, 20 L, 100L) to uniformly granulate the cells.

The principle of uniform sowing:

TideXcell ® Matrix Bed is designed to cut the area into small pieces and force the cells to flow in a radial direction instead of a vertical direction. Gradient effect in seeding stage can be minimized.

TideXcell ® -100 packaged with matrix tray (view from above):

This concept is achieved by packing the matrix bed with foam tapes of smaller diameter when the matrix is packed inside.

100% media exchange:

Continuous harvesting can be done in the TideXcell system due to 100% media exchange. This process is beneficial when culturing viruses to produce higher viral titers or for stem cell cultures that require switching to a different medium for differentiation.
Due to the separation of the platform (where cells reside) and the mixing vessel (where the mixing of cultures is taking place), the system is capable of completely collecting waste or conditioned media and feeding. in 100% fresh culture afterwards without harming the cultured cells.

Closed sampling for cell monitoring:

Closed system sampling can be performed in the TideXcell ® system. Each type of vessel has its own corresponding number of sampling ports.
A matrix cassette packed with 3D-configured carriers for optimal cell growth. Paper trays were stacked inside the matrix flask (2 L, 20 L, 100 L) to uniformly granulate the cells.

SCADA:

TideXcell® based monitoring and control architecture running on WonderWare SCADA. This provides a high-level process monitoring and data collection management. This software platform will ensure process control security, will support the control strategy, and will provide a method for collecting data and remote events (alarms) for continuous process monitoring. The SCADA platform also provides functions for graphical display, alerts, trends, and historical data storage.
TideXcell ® is at the core of Esco Aster, a contract development manufacturing organization (CDMO) that utilizes single-use adhesive bioreactors for bioremediation needs. Esco Aster focuses on process development, commercialization of new human and animal transducing (NTD) drugs, orphan drugs, as CMO for the partner factories TideXcell ® wants. outreach in ASEAN, ANZ, Africa.

Esco TideXcell ® Dimensional compare:

Bioreactor system Esco TideXcell ®

***You may be interested in GMGA's ultra-low temperature freezer - Esco Vietnam: https://gmga.vn/en/danh-muc/process-equipment/ultra-low-temperature-freezer/

III. Specifications bioreactor system Esco TideXcell ®

TideXcell ® Product Specifications TideXcell ® Incubation and Control Unit
Construction	External Carcass: 316 stainless steel
Dimension	125 (W) X 70 (D) X 115 (H) cm
Weight	240 kg
Electrical requirements	AC 220V 20A, 50/60 Hz, Single phase UPS (uninterrupted power supply) width 6kVA/4.2kW should be prepared by customers
Control Hardware (2-20L)	Flexible PC-based/DAQ industrial control interface; Solenoid valves/PID gauges/Pressure-vacuum motor NDIR CO2 diffusion type sensor
Control Hardware (50-100 L)	Siemens HMI/PLC based control structure Solenoid valves/PID gauges/Pressure-vacuum motor NDIR CO2 diffusion type sensor
Control Software	Siemens PLC-based control and monitoring structure Siemens HMI with 12.1" touchscreen Development environment: TIA Protal V13 SP1
Incubator	0 - 20% CO2 PID Control +8ºC~27ºC Operating Temperature Front view window; LED inside lighting Emergency power-off button
Connection	CPC nickel-coated brass quick connectors Electric connectors with locking-screw
Communication	9-pin Dsub RS-485 port : Modbus RTU protocol 2 USB Ports for import firmware / software upgrade and export trend data
Construction	264 W x 359 L X 170 H mm (10.4 x 14 x 6.7 inches)
Control Features	Simple user's administration
	Process page & Date viewer page
	Data logging/Parameters logging/Events logging
	Individual seed and amp
	Cultivation conditions setting with default values
	Automatic switch from seeding stage to cultivation stage up to 300 minutes
	Automatic air refreshing mechanism
Tidal control	800 ~ 1, 800 mL/min
Gas flow rate	0.8 – 20 LPM (depends on system size)
Alkaline addition	80 mL/min at 100 rpm
Perfusion rate	80 mL/min at 100 rpm
File export	Excel (.xlx)
pH control	4~10 ± 0.1
DO control	0%~100% ± 0.5%
CO2 control	0%~10% ± 0.3%
Protection	Over pressure protection (max. 1 bar)
	Liquid leaking protection
	Over suction protection
	Over time protection

TideXcell ® Mixing System
	Magnetic Stirrer Mixing System	Recirculation Thermostatic Mixing System	Stir-tank Mixing System
Construction	Magnetic stirrer 10 L, 20 L borosilicate glass vessel with stir bar for mixing	Recirculation Mixing with magnetic driven bearing-less impeller	Stir mixing with pre-installed impeller
Electrical Requirements	Monophase 3-threads AC 220V ± 10V 5A max 50/60 Hz	Single phase, AC 220v, 9A max, 50/60 Hz	Three phase, 230 VAC, 50/60 Hz
Capacity	10 L and 20 L	50 L, 100 L 200 L, 500 L, 1,000 L	30 L, 50 L, 100 L, 200 L, 500 L, 1,000 L
Control	100 – 1,500 rpm stir rate RT to +45°C temperature control	Pumping rate 0 – 21 LPM RT to +50ºC temperature control	80 – 1,000 rpm stir rate RT to +60ºC temperature control SIP system (sterilization in place)