Bioreactor tank small scale Esco BioXcell ® with stirrer

Buyer Rates Mã sản phẩm: 16765

Model: BioXcell ®
Manufacturer: Esco VacciXcell
Status: Stocking
Guarantee: 12 months
Price: Contact

The bioreactor system in a stirring tank has been around for a long time, since the beginning of the culture of different agents such as cells, enzymes or antibodies.

Bioreactor tank small scale Esco BioXcell ® with stirrer is a stirrer bioreactor for small scale research and development applications, available in single or multiple use vessels.

Description

Bioreactor tank small scale Esco BioXcell ® with stirrer – Great versatility for successful microbial culture.

I. Specifications of Esco BioXcell ® paddle cell culture machine

  • This compact Esco BioXcell ® stirred tank bioreactor features a small footprint to save space in your laboratory.
  • BioXcell ® control towers are combined with 2 L or 10 L flasks for microbial, fermentation and cell culture applications. Whether you are in the early stages of research and development, this bioreactor is available in flexible configurations to fit your needs.

Principle of stirring in Esco BioXcell ®:

  • The impellers are interchangeable in this Esco BioXcell ® stirred tank bioreactor; provides sufficient rapid stirring for efficient distribution and homogenization within the bioreactor.
  • Different impeller designs provide different fluid dynamics to utilize suitable mass transfer proteins for higher product yield.

Advantages of agitated bioreactor  Esco BioXcell ®:

Bioreactor tank small scale Esco BioXcell ® with stirrer

  • Perfect fit for research and development
  • Combination technology: multiple glass jars or single-use jars
    • 1:2 for mammalian cells
    • 1:3 for microorganisms/fermentation
  • Expandable from bench to research
  • Siemens PLC HMI software with user-friendly touch screen interface; Intuitive for real-time monitoring
  • Compact design to save critical lab space
  • Configurable peristaltic pumps. Easily assemble tubes for fluid addition or removal
  • Rotameters – Air Flow Control
  • Interchangeable impeller/cutter to solve user’s requirement
  • Processing Modes: Batch, Fed-Batch, and Perfusion.

Applications of Esco BioXcell ®:

  • Microbial Cells
  • Insect cells
  • Mushroom
  • Mammalian cells in suspension.

BioXcell ® control tower:

Bioreactor tank small scale Esco BioXcell ® with stirrer

II. Highlights of the Esco BioXcell ® bioreactor

esco-bioxcell-co-canh-khuay Bioreactor tank small scale Esco BioXcell ® with stirrer

Combined technology:

  • Single-use components facilitate a more robust approach as it eliminates cleaning validation steps and more. The Esco BioXcell ® bioreactor is a hybrid technology that can choose to use a single-use or multiple-use flask. Sterilizers such as glass and stainless are mainly used in laboratories for ease of production scale-up. Reusable vessels have a long history in the manufacturing areas of the bioprocess industry. Not only is there a wealth of experience and established protocols in single use, but also the capacity it can provide as opposed to single use.
  • This hybrid technology maintains production capacity while building confidence in user requirements. Deployment of single-use systems is more efficient and cost-effective while hybrid technology, even with established methods and protocols, provides a practical way to culture microorganisms at production scale.
FAVORABLE

Single use

Use a lot of times
Increased flexibility of product base

Well established; conventional method

Pollution from low to zero

Implementation of other technologies through fixed pipeline
Reduce capital costs such as testing equipment and facilities

Available in large capacity

No need to clean

Advanced measurement and control parameters
DEFECT

Single use

Use a lot of times
Limited scalability (not suitable for production scale)

Infrastructure is not flexible

Use a lot of times

Clean and confirm the process
Learning curve (adapting to new technology)

High utility costs

Damaged main ship parts may cause leakage

Piping problems
Extracts and detergents

Contamination can occur if not cleaned and sterilized properly

Propeller design:

  • The impeller inside the Esco BioXcell ® stirred bioreactor is suitable for internal mixing of different ingredients; to achieve homogeneity. It is also responsible for breaking the bubble formation during aeration in culture. Propellers are usually mounted top-down or bottom-up or side-mounted. It is installed in a propeller shaft that is usually circular and oriented perpendicular to the bottom of the bioreactor.

Esco BioXcell ® with stirrer

  • Based on the bioreactor’s liquid viscosity, different impellers should be used to achieve higher tip speeds corresponding to the running culture conditions. There are propellers, turbines, paddles, and more that operate at faster speeds than standard speeds. As scale increases, proper mixing is important to reduce adverse effects during microbial culture.
Radial impeller:
  • The Rushton turbine is the best example of a radial flow propeller commonly used in a standard stirrer bioreactor. This type of propeller offers good air dispersion and bubble breaking resulting in high mass transfer.

Bioreactor tank small scale Esco BioXcell ® with stirrer

Axial line propeller:
  • The propeller-type impeller allows the liquid flow directly inside the bioreactor to be stirred. The propeller styles commonly used for cultures have low viscosity due to their relatively higher tip speeds. Since they are generally operated faster, one must ensure that gas-liquid dispersion is achieved.

Bioreactor tank small scale Esco BioXcell ® with stirrer

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III. Thông số kỹ thuật bioreactor tank small scale Esco BioXcell ® with stirrer

UTILITY

CONTROL TOWER Electrical connection

230 VAC Single Phase 30A

Housing

Stainless Steel
Water

Quick connect
Water supply pressure requirement: 1.5 M

Gas Supply (air, O2, N2, CO2)

Push-connect fittings accept ¼ in. tubing or hose barb fitting
Requirement: 10psig (0.69 barg)
Overall Dimension (W x D x H)

350 x 692 x 925 mm

Vinterface

Colored Touch Screen Siemens HMI TP700
Siemens PLC S7 1200
Features

Real-time dynamic display

Record Output

USB port to save data to an external flash drive
Vessel Feature BioXcell® 2 L

BioXcell® 10 L

Nominal Volume

2 L 10 L
Working Volume 1-2 L

3-10 L

Tank Nominal Weight

5 kg 852 mm
Maximum Height (with condenser) 520 mm

852 mm

Maximum Outer Diameter

220 mm 220 mm
Agitation Drive

Small AC servo motor with automatic feedback compensation
capable of low speed, high torque

Sensor

Incremental encoder TTL 2500 ppr
Range

1-1200 rpm

Precision

1 rpm
Impeller

2x Rushton Turbine Impeller
*Configurable designs based on user requirement

Baffles

Inclusive in Standard Vessel
Temperature Operating Conditions

Ambient Temperature

Precision

±0.01
Sensor

PT 100

Control

Heating Pad
pH Range

2-12

Precision

±0.01
Probe

Analog/Digital Mettler Toledo

Probe Length

BioXcell® 2 L: 225 mm
BioXcell® 10 L: 325 mm
Control

Fermentation: Acid/Alkali Addition
Cell Culture: CO2 /Alkali Addition

DO

Range

Display Range: 0-200%
Setting Range: 0-100%
Precision

±0.01%

Probe

Analog/Digital Mettler Toledo
Probe Length

BioXcell® 2 L: 225 mm
BioXcell® 10 L: 325 mm

Control

Gas Injection through Sparger
Delivery

Ring Sparger

Options

Mass flow controller
Oxygen Enrichment Device
Second Gas Port (O2, N2, CO2, or other gases)
Oxygen Transfer Rate

Condenser

Filter 0. 2µm PTFE filter
Condenser

Stainless Steel Condenser

Peristaltic Pumps

Number 4 built-in, configurable peristaltic pumps
Configurations

Alkali, Acid, Feed, Antifoam

Pump head

Watson Marlow or Equivalent
Tube Sizes

Default: 3.2 mm
*Configurable depending on user requiremnt

Fixed Speed

20-200rpm
Flowrate

9.4 to 95mL/min

***Detailed product specification sheet: BioXcell® Small-Scale Stirred Tank Bioreactor.

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