Fermentation bioreactor system Esco StirCradle™ -Pro

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Model: StirCradle ™ -Pro
Manufacturer: Esco VacciXcell
Status: Stocking
Guarantee: 12 months
Price: Contact

Fermentation bioreactor system The all stainless steel Esco StirCradle™ -Pro is designed with an automated 5-step cycle SIP system for both culture media and reactors.

Esco VacciXcell offers a wide range of StirCradle™ -Pro large scale bioreactor capacities from 20L to 1000L.

However, custom reactor sizes are available if the user requires a custom bioreactor for large-scale cell culture.

Description

Fermentation bioreactor system Esco StirCradle™ -Pro comes in various advanced designs and assemblies to facilitate fermentation/culturing processes, including a reactor design that eliminates blind spots and increases rates oxygen storage, lifting system for easy cleaning of the reactor and LED lights for easy viewing in the culture tank.

The fermentation bioreactor system Esco StirCradle™ -Pro from lab to pilot and production scale by providing analytical data as a reference for scaling conditions. In addition to custom sizes, the Esco StirCradle™ -Pro offers special vessel development and parameter programming to help speed up testing. Esco Vaccixcell provides complete documentation of the system components.

I. Specification Esco StirCradle™ -Pro large-scale cell culture machine

Intelligent control system:

  • Fermentation bioreactor system Esco StirCradle™ -Pro uses SCADA system
  • 15” color HMI touch screen with real time 3D view of fermentation/culturing process and user friendly display
  • Real-time cultural trend chart data logging. Internal persistent write memory:
    • Up to 12.5 days: 1 data every 30 seconds
    • Up to 25 days: 1 data per minute
    • Up to 50 days: 1 data every 2 minutes
  • Fast download via USB in .xls . format
  • Optional documentation for compliance with 21 CFR Part 11
  • Share remotely via ethernet port or wireless sharing device.

Advanced design of reactor and components:

  • Over 70% of the working volume, the tank is designed to eliminate blind spots
  • LED light for easy viewing inside the tank
  • Many options for transplanting:
    • Advanced Short Quantitative Gateway Rapid Release
    • Bacterial port inoculation
    • Needle diaphragm injection
  • Φ25 Standard configurable electrode ports for pH and DO
  • All contact surfaces inside the tank are polished with a MP # 400 + EP machine and the outside of the tank with a mechanical MP # 300 + EP machine
  • Condenser housing and tubes:
    • Inner material: SUS316
    • Outer pipe: SUS304
  • Quick disassembly for cleaning to facilitate cleaning
  • The safe design of the pipeline allows for simple disassembly and replacement without affecting the process
  • The impeller is designed to effectively achieve a high bubble dispersion rate and kLa . value
  • Connection clamp Sanitary clamp Applies to Pressure Sensor, Diaphragm Manometer Port, and Feed Port Preparation.

Built-in configurable pump:

  • Four (4) built-in configurable peristaltic pumps for liquid replenishment
    Each pump can be set as Alkaline, Acid, Feed or Antifoam
    The pump can be calibrated and the flow can be set using the % speed

Disinfection in place (SIP):

  • Automated SIP system for both reactor and culture media
  • The SIP program has 5 steps: Heating 1, Heating 2, Sterilizing, Cooling 1 and Cooling 2
  • Optional cleaning-in-place (CIP) system.

Esco VacciXcell StirCradle™ -Pro provides a thorough package of documentation and validation:

  • The authentication package includes the following:
    • Document certificate
    • Production control panel
    • Welding Profile
    • Pressure test report
    • Operating manual
    • Device sketch diagram
    • P&ID chart
    • Power Loop Diagram
    • Ra test report
  • Optional IQ/OQ/PQ document.

Other features of the Esco StirCradle™ -Pro fermentation reactor:

  • Automated Disinfection in Place (SIP)
  • Batch, batch, continuous batch, semi-continuous and high-density batch systems
  • Enhanced resistance high torque transmission and rack (SUS304 + EP surface treatment).
  • Online repeat sterilization Mechanical shaft seal Dry cartridge sample.
  • Sterilizable quick release air duct (Anti-clogging High Dispersion Air Divider), which can be easily disassembled and cleaned.
  • High sensitive speed sensor (1,000Hz) using PID Automatic Calculation Feedback Compensated output to Inverter stepless speed change (Rotation speed can be controlled at ±1 rpm).
  • Coolant Type Y Filter, Steam Filter, Steam Pressure Reducing Valve, Air Double Side Prefilter Group, and Air Pressure
  • Reducing Valve Group.
  • Pipeline controller:
    • Sterilization control valve
    • Manifold pipe temperature control
  • Sterile ventilation control manifold
    • Pipeline pressure manifolds of the intake control valve metering discharge tank (consisting of four groups/sets)
    • Transfer inoculation control manifold pipeline.
  • In the event of a power failure, positive pressure is kept in the tank for more than 24 hours. Parameters can be controlled.

II. Outstanding advantages of fermentation bioreactor system Esco StirCradle™ -Pro

In situ sterilization screen (SIP):

  • The SIP screen shows a real-time view of the sterilization process
  • Displays the current step of the sterilization process
  • Show valve open or close
  • Displays current and set values for sterilization parameters: temperature, agitation, air, pressure and time
    5-step sterilization process:
  • Heating 1 – 100% steam in the heater
  • Heating 2 – Steam in heating jacket and air filter
  • Cooling 1 – Using air for cooling system down to 50 – 60oC
  • Cooling 2 – Uses cold/tap water to completely cool the system
  • Disinfection module for both reactor culture media.

Fermentation bioreactor system Esco StirCradle™ -Pro

Ergonomic display:

  • Real-time dynamic display of the culture
  • Displays set value and current value of all parameters, valve opening and closing and total volume of liquid added by each pump
  • User can switch between automatic and manual control of parameters
  • Show total culture time.

Fermentation bioreactor system Esco StirCradle™ -Pro

Feed settings screen:

  • The user can set the flow rate for each pump. Once the flow rate for each pump is set, the flow rate of each pump can be controlled via speed percentage.
  • The user can set the pump in one of the following ways:
  • On/Off: User controls pump regardless of parameter value
  • DO Stat: Pump is controlled by changes in DO value, depending on user-set criteria
  • The pH Stat Pump is controlled by the change of the pH value, depending on the criteria set by the user.

Fermentation bioreactor system Esco StirCradle™ -Pro

Step control setting screen:

  • User can set 50-step control program for temperature, agitation, pH, DO, aeration and feeding
  • Up to 20 step programs can be saved for each parameter. Saved programs can be loaded, modified and deleted.
  • The user can select the point on a step program at which the program will start
  • 50-step parameter control designed to easily and automate user control of the culture/fermentation process.

Esco StirCradle™ -Pro

Setup and sterilization screen:

  • User can set parameter values ​​for sterilization cycle and culture process
  • For the sterilization process, the user sets the end temperature for each sterilization step, stirring speed, pressure, airflow and total sterilization time.
  • For the culture setting, the user can choose automatic or stepwise control over the parameters:
  • Automatic: controlled by user set value (SV)
  • Step: controlled by user step setting
  • The user can set one of the following DO control modes they require:
  • Excitement speed
  • Ventilation Control
  • Excitation rate -> Air -> O2
  • Ventilation -> Excitation rate -> O2
  • The user can specify one of the following settings for the peristaltic pump:
  • No: no pumping action
  • Acid: add acid
  • Alkl: alkaline supplement
  • AF: added antifoam
  • Feed: supplement feed
  • Foaming can be controlled with one of two options:
  • Anti-foam – except anti-foam
  • Defoam – use pressure.

esco-stircradle-pro

III. Application of Esco StirCradle™ -Pro

  • Pilot and scale production of microbial fermentation processes such as yeasts, bacteria and fungi (large-scale bioreactors for culturing bacteria)
  • Pilot scale and production of cells such as insect cells and suspended mammalian cells (large-scale bioreactors for suspension culture)
  • Pilot and scale production of biopharmaceuticals such as recombinant proteins, vaccines and monoclonal antibodies.

***You may be interested in GMGA biosafety cabinets – Esco Vietnam: https://gmga.vn/en/danh-muc/process-equipment/biological-safety-cabinets/

IV. Specifications fermentation bioreactor system Esco StirCradle™ -Pro

GENERAL SPECIFICATION

Features Unit StirCradle™-Pro 20 StirCradle™-Pro 30 StirCradle™-Pro 50 StirCradle™-Pro 100 StirCradle™-Pro 200 StirCradle™-Pro 500

StirCradle™-Pro 1000

Nominal Volume

L 20 30 50 100 200 500 1000
Total Volume L 25 34 56 126 220 620

1120

Working Volume

L 15 20 35 75 150 400 750
Tank Inner Diameter (D) mm 260 260 310 400 480 680

830

Tank Depth

mm 450 620 730 980 1200 1650 2000
Mixing Blade Diameter

NA

D / 3 D / 2,5 D / 3 D / 2,5 D / 3 D / 2,5 D / 3 D / 2,5 D / 3 D / 2,5 D / 3 D / 2,5 D / 3

D / 2,5

mm 87 104 87 104 103 124 133 160 160 192 227 272 277

332

Agitation

Speed rpm 80-1000 80-1000 80-800 60-600 60-600 60-550 40-400 30-300
Precision rpm

±1

Blade tip maximum speed

m/s 3.6 4.4 3.6 4.4 4.4 5.2 4.2 5 5 5 5.9 5.7 5.8 5.2
pH Range NA

0-14

Precision

NA ±0.01
Temperature Precision °C

±0.01

Heating

NA Hot water tank
Cooling NA

Tap or Chilled water tank

Dissolved Oxygen

Range % 0 – 200
Precision %

Display: ±0.1 | Control: ±0.2-0.5

Noise Level

dBA <100
Air flow (0.3 kg/cm2 culture) wm 2.3 2.3 2 2 2.1 2

2.2

Total electricity demand 220 V, 3Φ

A 7 8 10 20 35 60 100
Steam demand (2 kg/cm2-G 133°C kg/hr 15 20 30 60 130 250

300

Air Demand (2 kg/cm2-G

1/min 36 48 75 159 333 848 36
Cooling Water Demand (2 kg/cm2-G 20°C m3/hr 0.3 0.4 0.5 0.8 1.5 2.5

4

Continue Caliber

Stream A 8 10 10 15 25 25 25
Air A 8 10 10 15 20 25

40

Water

A 8 10 10 15 20 25

25

Fermenter Sterilization

Sterilization-in-Place (SIP)

***Detailed product specification sheet: StirCradle™-Pro Large Scale Stirred Tank Bioreactor.

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