Cell harvesting system Esco TideXcell ® (TXLHS)

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Cell harvesting system Esco TideXcell ® (TXLHS) Gentle Giant's harvesting partner

I. Specification of the Esco TideXcell ® Automatic Cell Harvester (TXLHS)

Tide motion in cell harvesting system Esco TideXcell ® (TXLHS):

[video width="1280" height="720" mp4="https://gmga.vn/wp-content/uploads/2021/11/Máy-thu-hoạch-tế-bào-tự-dộng-Esco-TideXcell-®-TXLHS_01.mp4" autoplay="true"][/video]

Features of Esco TideXcell ® (TXLHS):

TThe entire harvesting process can be set up from washing to harvesting cells in a self-contained, automatic cell harvester.
Suitable for cell harvesting from 2L TideXcell ® matrix flasks to 20L matrix flasks
Cell seed source support for TideXcell™-010 up to TideXcell™-100 systems.
Harvest live cells within 1 to 3 hours (harvest time depends on harvest cycle).
Up to 10 11 tiles can be recovered with over 95% survivability from a single TXLHS unit.
Four (4) built-in peristaltic pumps (with option to add up to 3 more) with assignable functions.

Please note: Cell harvesting efficiency depends on the cell line used with the adherent cell harvester. Cell harvesting system Esco TideXcell ® (TXLHS)

Cell harvesting system Esco TideXcell ® (TXLHS)

II. Esco TideXcell ® (TXLHS) - Working principle

The TideXcell™ harvesting system uses a similar and conventional cell harvesting concept by digesting enzymatic treatment and separating the cells from the attached substrate. Procedures include: Cell harvesting system Esco TideXcell ® (TXLHS)

Setting:

Mount and secure the TideXcell™ Matrix flask in the TideXcell™ Harvest System and connect the TideXcell™ matrix flask to the tubular manifolds. It will act as a conduit for the introduction of phosphate-buffered saline (PBS), enzymes (usually Tryple Select, Accumax and Collagenase among others), enzyme inhibitors (when using culture media that does not contain serum), culture medium and waste container.
These six tubes connect to the Matrix Vessel via a manifold.

Wash:

Wash the substrate with phosphate-buffered saline or an equivalent solution to remove serum that may inhibit enzyme activity in the following step.

Enzyme treatment:

Immerse the substrate with a chosen enzyme to digest the cells until the cells round up to separate.

Cell separation:

Shake the matrix jar together with the matrix to remove cells from the porous matrix.

Collect:

Collect cells by rinsing the substrate with cell culture medium or an equivalent solution and collect cells into the harvesting tank.

III. Advantages of cell harvesting system Esco TideXcell ® (TXLHS)

Suitable for cell harvesting from TideXcell™ 2L Matrix Vessels to 20L Matrix Vessels.
Cell seed source support for TideXcell™-010 up to TideXcell™-100 systems.
Harvest live animal cells within 1 to 3 hours (harvest time depends on harvest cycle).
The entire harvesting process is done automatically in a closed system. Manual operation is also available.
Can recover up to 1011 tiles with over 90% survivability from a THS . unit.

IV. Application of the Esco TideXcell ® cell harvester

TideXcell ® Automated Cell Harvester (TXLHS) for adherent cell culture including but not limited to: Insect Cells, Mammal Cells, Stem Cells
Extending biomass for seed training from 2D to 3D
Autologous and allogeneic cell therapy
Intracellular virus.

***You may be interested in GMGA fermentation and bioreactors - Esco Vietnam: https://gmga.vn/en/danh-muc/process-equipment/bioreactors-and-fermenters/

V. Specifications cell harvesting system Esco TideXcell ® (TXLHS)

Infrastructure	Exterior dimesion (WxDxH)	Controller unit: 80cm x 91cm x 181.2cm Main chamber: 110cm x 110cm x 188.7cm
	Weight	1,330 kg not including 2/20L adaptor (18kg)
	Power	Single phase, AC, 220 V, 50/50 Hz
	Gas Input	At least 0.5 MPa from the air source
	Other	RS485 communication port
Function: Rotation	Functional unit	Rotary motor
	Work	750 W
	Range	0°~180° (back and forth)
	Rate	0~10 rpm ± 2 rpm
	Period	0~999 sec ± 5 sec
Function: Shake	Functional unit	Shake motor
	Work	3.5 kW at 300 rpm
	Range	13cmmax
	Rate	50~300 rpm ± 10 rpm
	Period	0~999 sec ± 5 sec(16.6 mins)
Function: Break	Functional unit	Damper
Function: Feed and Harvest	Functional unit	6 Peristaltic pumps (Harvest Out, Buffer Saline In, Enzyme In, Inhibition In, Culture Medium In, Waste Recovery)
	Rate	20 - 250 rpm ± 5 rpm
	Period	0~999 sec ± 5 sec
	Tubing	ID 9.6 mm(3/8")*WT 32 mm(1/8")
Consumable: Matrix vessel	Volume	2 L and 20 L
Consumable: Matrix vessel	Material	PP
Consumable: Tubing set	Type	ID:3/8", OD:5/8"
Tool: Torque wrench	Range	10~45 N•m
Control: Touch panel	Size	10.4" color
Modes	Automated and manual
Efficiency	Cell recovery rate	2L Vessel: >90% recovery rate
Efficiency	Cell recovery rate	20L Vessel: 70%~90% recovery rate