Biological reactor 4 in 1 Esco (HBR) VXL™

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This biological reactor 4 in 1 Esco (HBR) VXL™ is best used for research and development before scaling up to a larger bioreactor system. The VXL™ hybrid bioreactor can also perform different process modes including batch, batch, and infusion.

I. Specification Esco VXL™ cell culture machine (HBR)

Biological reactor 4 in 1 Esco (HBR) VXL™ automatically controls pH, DO, aeration, foaming, temperature, agitation and level
Glass water tank heats up to 37°C (±)0.3 in just 30 minutes
Biological reactor 4 in 1 Esco (HBR) VXL™ inoculation and sampling in a closed system
Working volume up to 50 L
Touch screen HMI controller. A touch screen HMI controller can be connected.

Biological reactor 4 in 1 Esco (HBR) VXL™

Tidal movements in VXL™ Hybrid:

[video width="600" height="400" mp4="https://gmga.vn/wp-content/uploads/2021/11/Máy-nuôi-cấy-tế-bào-Esco-VXL-™-HBR_01.mp4" autoplay="true"][/video]

VXL™ Hybrid - Tide configuration:

VXL™ Hybrid - Stirring tank configuration:

Applications of biological reactor 4 in 1 Esco (HBR) VXL™:

Research and Development / Scaling Research
Vaccines for people
Monoclonal antibodies
Cell therapy
Diagnose
Small-scale secret biological production
Exocrine vesicles (eg, Exosomes)
Viral Seeds (VLPs)
Communication Development
Animal vaccines
Biosimilars / Biobetters
Gene therapy
Pre-screening
Secreted virus (eg Rotavirus or Hog Cholera)
Protein / Recombinant Protein
Virus Vector (eg: AAV/LV or Human Immunodeficiency Virus)

***You may be interested in the GMGA nucleic acid extraction machine - Esco Vietnam: https://gmga.vn/en/danh-muc/process-equipment/nucleic-acid-extraction-system/

II. Specifications biological reactor 4 in 1 Esco (HBR) VXL™

Hybrid Bioreactor (HBR) Control Unit
Control Unit Weight
Single	80 kg (177lbs)
Control Unit Dimensions
Single	W460x D 637 x H 903 mm
Utility Connections
Power Supply	220 volts, max power consumption 5A
Gases	4x6mm external tubing diameter
	Gas supply pressure, 10psi
	oil & moisture-free
Water	Water supply pressure- 1.5 M
	Flow rate up to 10-12 lpm
	Minimum temperature 13-14°C
	L/S 35 Silicone for tubing
Control Unit
Housing	Stainless Steel, AISI 304
Display	HMI
Resolution	800x600
SCADA Communication	Ethernet
Safety valve gas pressure	10 psi for Matrix Reactor Vessel and Suspension Vessel
Water inlet pressure reduction	0.15bar, integrated pressure control
Motor Drive
Direct Drive	Power: 400W

Reactor Vessel Material
1 Liter and 7 Liter vessel	Borosilicate glass
Total Volume: 1.5L and 8.2L	Borosilicate glass
14 Liter vessel	Borosilicate glass/Stainless Steel
25 Liter vessel	Stainless Steel
50 Liter vessel	Stainless Steel
Vessel Dimensions
1 Liter	D 116 x H 148 mm
7 Liter	D 190 x H 320 mm
14 Liter	D 240 x H 450mm
(scale up sizes for 1L-50L vessel is applicable for Tide Motion Principle only)

Sensor \| Measurement Range \| Display Accuracy	Description
Temperature	PT-100 class A ; Deviation: ±(0.15+0.00 \|t\| ); 0°C-100°C
Dissolved oxygen	Measurement Principle	Amperometric/ Polarographic
	Working Conditions
	Pressure resistance measurement	0.2-6 bar absolute
	Pressure resistance measurement	(2.9-87.0 psi absolute)
	Mechanical resistance measurement	max. 12 bar absolute
	Mechanical resistance measurement	(174.0 psi absolute)
	Measuring temperature range	0...80°C (32…176 °F)
	Temperature range	-5…140°C (23…284°F) (autoclavable)
	Construction
	Temperature compensation	Automatic with built-in RTD
	Cable connection	VarioPin (IP 68) straight or angled K8S straight (digital ISM sensors)
	O-ring materia	Silicone FDA and USPP VI approved
	Membrane material	PTFE/Silicone/PTFE (reinforced with steel mesh)
	Wetted metal parts	Stainless steel Special material on request
	Surface roughness of wetted metal parts (ISO 1320:1992)	N5 (< 0.4m [16in])
	Quick disconnect interior body	Standard
	Cathode	Pt
	Anode	Ag
	Guard ring	No
	Dimensions
	Sensor diameter	12 or 25 mm (0.47” or 0.96”)
	Immersion length (a) for 12 mm sensor	70, 120, 220, 320, 420 mm. (2.8, 4.7, 8.66, 12.6, 16.54”)
	Immersion length (a) for 25 mm sensor	80, 160, 260, 360 mm (3.15, 6.3, 10.24, 10.17”)
	Performances
	Detection limit	6ppb
	Accuracy	≤ ±(1% + 6 ppb) of reading in liquids
	Response time at 25°C/77°F (air – N2)	98% of final value <90s
	Sensor signal in ambient air (25°C/ 77°F)	50…110nA
	Residual signal in oxygen-free medium	<0.1% of the signal in ambient air
	Maximum flow error	≤ 5%
	Certification
	EHEDG, 3A	Yes
	3.1B (EN 10204.3/1.b)	Yes
	ATEX certificate	Yes
	FM Approval	Yes
	FDA/USP VI	Yes
	Quality control	Yes
pH	Measuring range	pH 0…14
	Temperature	0…80°C for operation 0…140°C for sterilization
	Pressure resistance	Up to overpressure of max. 6 bar (87psi)
	Reference system	Argenthal (Ag/AgCl)
	Reference electrolyte	Gel electrolyte
	Diaphragm	1 ceramic diaphragm
	Glass membrane	HA, high alkali glass quality
	Glass shaft	Ø12 mm
	Plug head	K8S, Pg 13.5 thread
Foam Control	Teflon insulated stainless steel
Level	Teflon insulated stainless steel
Turbidity	Dimension	W 270 x D 200 x H 300 mm
	Measuring principle	Backscatter, 1-fiber
	Sensor material	DIN 1.4435 (316L)
	Sensor diameter	12 mm
	Insertion length	120, 205, 297, or 407 mm
	Process connection	Pg 13.5
	Measuring range
	Formazin Turbidity Units 1	10…40000 FTU
	Suspended Solids (Diatomaceous earth as reference)	0…250 g/L
	Design
	Cable connectors	SMA
	Cable lengths	3m (10ft) optica
	Cable type	Duplex HCS fiber, fixed
	Wetted parts
	Metals	DIN 1.4435 (316L)
	Plastic	None
	O-ring	Viton-FDA
	Sapphire spigot for fiber	None
	Sapphire window for fiber protection	None
	Working conditions
	Pressure range	0…6 bar (0…87psi)
Redox	Dimension	W 270 x D 170 x H 230 mm
	Measuring range	pH 0…12
	Temperature	0…100°C in operation 0…130°C for sterilization
	Pressure resistance	From vacuum up to a process pressure of max 2.5 bar (36psi)
	Reference system	Argenthal (Ag/AgCl)
	Reference electrolyte	Pressurized gel electrolyte
	Diaphragm	1 ceramic diaphragm
	Glass shaft	Ø12 mm
	Plug head	K8S, Pg 13.5 thread
RM load cells	Weight:100 kg Dimensions: (in mm) 330 X 330

Vessel Sizing and Volume
Model	M-1000	M-5000
Total Volume (L)	1.5	8.2
Maximum Working Volume (L) for Suspension Culture	0.6-1.1	4.5-7
Depth (mm)	116	190
Height (mm)	148	320
Recommended BioNOC II Matrix volume [ml]	180	1000
Recommended amount BioNOC II Matrix in grams	10	55
Aspect Ratio	1:2.5 (for suspension) 1:3 (for microbial culture)

*Specifications of 4-in 1 VXL Hybrid Bioreactor**	Adherent Cell Culture		Suspension Cell Culture		Fermentation		Microcarrier-Based Cell Culture
Model	M-1000	M-5000	M-1000	M-5000	M-1000	M-5000	M-1000	M-5000
Vessel Material	Borosilicate Glass
Temperature Range	20ºC - 70ºC Precision: 0.1 ºC	10 ºC-70 ºC Precision: 0.1 ºC	20 ºC-70 ºC Precision: 0.1 ºC	10 ºC-70 ºC Precision: 0.1 ºC	20 ºC-70 ºC Precision: 0.1 ºC	10 ºC-70 ºC Precision: 0.1 ºC	20 ºC-70 ºC Precision: 0.1 ºC	10 ºC-70 ºC Precision: 0.1 ºC
Baffle	N/A		YES		YES		N/A
Top Stirrer Motor	10-1200rpm
Impeller speed	25-200r pm		50-1200 rpm		50-1200 rpm		25-400 rpm
Impeller Design**	Small 6-Blade Rushton Turbine		3-Pitched-Blade Turbine and 3-Marine-Blade Propeller		Large 6-Blade Rushton Turbine		3-Pitched-Blade Turbine and 3-Marine-Blade Propeller
Ventilation	Ring Sparger		Micro-Sparger		Ring Sparger		Ring Sparger
Drive Method	Tide: KNF brushless motor with air pump, controlled by PID or constant voltage direct drive. Mixing: Top direct servo motor with PID/PWM control				Mixing: Top direct servo motor with PID/PWM control
Condenser	Stainless steel condenser with 0.2 um disk type or cartridge type filter
pH Range	pH 4-14 Precision: 0.01
DO Range	0-100 % Precision: 0.01%
Aeration	10L/min Precision: 2%
Emerging Time	0-100mins		N/A
Submerging Time	0-100mins		N/A
Liquid Level Control	High Level Sensor		Electronic Scale
Sampling	liquid: sampling bottle; matrix: sample port		liquid: sampling bottle
Foaming Control	N/A		YES		YES		YES
Control Unit	8.4” HMI
Specifications are subject to change without prior notice