Biological reactor 4 in 1 Esco (HBR) VXL™

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Model: VXL ™
Manufacturer: ESCO
Status: Stocking
Guarantee: 12 months
Price: Contact

Biological reactor 4 in 1 Esco (HBR) VXL™ is a versatile bioreactor that can perform four types of culture, namely: adherent culture using macro-carrier, adherent culture using micro-carriers, suspension cultures, and fermentations.

Description

This biological reactor 4 in 1 Esco (HBR) VXL™ is best used for research and development before scaling up to a larger bioreactor system. The VXL™ hybrid bioreactor can also perform different process modes including batch, batch, and infusion.

I. Specification Esco VXL™ cell culture machine (HBR)

  • Biological reactor 4 in 1 Esco (HBR) VXL™ automatically controls pH, DO, aeration, foaming, temperature, agitation and level
  • Glass water tank heats up to 37°C (±)0.3 in just 30 minutes
  • Biological reactor 4 in 1 Esco (HBR) VXL™ inoculation and sampling in a closed system
  • Working volume up to 50 L
  • Touch screen HMI controller. A touch screen HMI controller can be connected.

Biological reactor 4 in 1 Esco (HBR) VXL™

Tidal movements in VXL™ Hybrid:

VXL™ Hybrid – Tide configuration:

Biological reactor 4 in 1 Esco (HBR) VXL™

VXL™ Hybrid – Stirring tank configuration:

Biological reactor 4 in 1 Esco (HBR) VXL™

Applications of biological reactor 4 in 1 Esco (HBR) VXL™:

  • Research and Development / Scaling Research
  • Vaccines for people
  • Monoclonal antibodies
  • Cell therapy
  • Diagnose
  • Small-scale secret biological production
  • Exocrine vesicles (eg, Exosomes)
  • Viral Seeds (VLPs)
  • Communication Development
  • Animal vaccines
  • Biosimilars / Biobetters
  • Gene therapy
  • Pre-screening
  • Secreted virus (eg Rotavirus or Hog Cholera)
  • Protein / Recombinant Protein
  • Virus Vector (eg: AAV/LV or Human Immunodeficiency Virus)

Esco (HBR) VXL™

***You may be interested in the GMGA nucleic acid extraction machine – Esco Vietnam: https://gmga.vn/en/danh-muc/process-equipment/nucleic-acid-extraction-system/

II. Specifications biological reactor 4 in 1 Esco (HBR) VXL™

Hybrid Bioreactor (HBR) Control Unit

Control Unit Weight

Single

80 kg (177lbs)

Control Unit Dimensions

Single

W460x D 637 x H 903 mm

Utility Connections

Power Supply

220 volts, max power consumption 5A

Gases

4x6mm external tubing diameter

Gas supply pressure, 10psi

oil & moisture-free

Water

Water supply pressure- 1.5 M

Flow rate up to 10-12 lpm

Minimum temperature 13-14°C

L/S 35 Silicone for tubing

Control Unit

Housing

Stainless Steel, AISI 304
Display

HMI

Resolution

800×600
SCADA Communication

Ethernet

Safety valve gas pressure

10 psi for Matrix Reactor Vessel and Suspension Vessel
Water inlet pressure reduction

0.15bar, integrated pressure control

Motor Drive

Direct Drive

Power: 400W

Reactor Vessel Material

1 Liter and 7 Liter vessel

Borosilicate glass

Total Volume: 1.5L and 8.2L

14 Liter vessel

Borosilicate glass/Stainless Steel

25 Liter vessel

Stainless Steel
50 Liter vessel

Stainless Steel

Vessel Dimensions

1 Liter

D 116 x H 148 mm

7 Liter

D 190 x H 320 mm
14 Liter

D 240 x H 450mm

(scale up sizes for 1L-50L vessel is applicable for Tide Motion Principle only)

Sensor | Measurement Range | Display Accuracy

Description

Temperature

PT-100 class A ; Deviation: ±(0.15+0.00 |t| ); 0°C-100°C

Dissolved oxygen

Measurement Principle

Amperometric/ Polarographic

Working Conditions

Pressure resistance measurement

0.2-6 bar absolute

(2.9-87.0 psi absolute)

Mechanical resistance measurement

max. 12 bar absolute

(174.0 psi absolute)

Measuring temperature range

0…80°C (32…176 °F)
Temperature range

-5…140°C (23…284°F)
(autoclavable)

Construction

Temperature compensation

Automatic with built-in RTD

Cable connection

VarioPin (IP 68) straight or angled K8S straight
(digital ISM sensors)
O-ring materia

Silicone FDA and USPP VI approved

Membrane material

PTFE/Silicone/PTFE
(reinforced with steel mesh)
Wetted metal parts

Stainless steel
Special material on request

Surface roughness of wetted metal parts (ISO 1320:1992)

N5 (< 0.4m [16in])
Quick disconnect interior body

Standard

Cathode

Pt
Anode

Ag

Guard ring

No

Dimensions

Sensor diameter

12 or 25 mm (0.47” or 0.96”)
Immersion length (a) for 12 mm sensor

70, 120, 220, 320, 420 mm.
(2.8, 4.7, 8.66, 12.6, 16.54”)

Immersion length (a) for 25 mm sensor

80, 160, 260, 360 mm
(3.15, 6.3, 10.24, 10.17”)

Performances

Detection limit

6ppb
Accuracy

≤ ±(1% + 6 ppb)
of reading in liquids

Response time at 25°C/77°F (air – N2)

98% of final value <90s
Sensor signal in ambient air (25°C/ 77°F)

50…110nA

Residual signal in oxygen-free medium

<0.1% of the signal in ambient air
Maximum flow error

≤ 5%

Certification

EHEDG, 3A

Yes

3.1B (EN 10204.3/1.b)

Yes
ATEX certificate

Yes

FM Approval

Yes
FDA/USP VI

Yes

Quality control

Yes
pH Measuring range

pH 0…14

Temperature

0…80°C for operation
0…140°C for sterilization
Pressure resistance

Up to overpressure of max. 6 bar (87psi)

Reference system

Argenthal (Ag/AgCl)
Reference electrolyte

Gel electrolyte

Diaphragm

1 ceramic diaphragm
Glass membrane

HA, high alkali glass quality

Glass shaft

Ø12 mm
Plug head

K8S, Pg 13.5 thread

Foam Control

Teflon insulated stainless steel
Level

Teflon insulated stainless steel

Turbidity

Dimension

W 270 x D 200 x H 300 mm
Measuring principle

Backscatter, 1-fiber

Sensor material

DIN 1.4435 (316L)
Sensor diameter

12 mm

Insertion length

120, 205, 297, or 407 mm
Process connection

Pg 13.5

Measuring range

Formazin Turbidity Units 1

10…40000 FTU

Suspended Solids (Diatomaceous earth as reference)

0…250 g/L

Design

Cable connectors

SMA
Cable lengths

3m (10ft) optica

Cable type

Duplex HCS fiber, fixed

Wetted parts

Metals

DIN 1.4435 (316L)
Plastic

None

O-ring

Viton-FDA
Sapphire spigot for fiber

None

Sapphire window for fiber protection

None

Working conditions

Pressure range

0…6 bar (0…87psi)
Redox Dimension

W 270 x D 170 x H 230 mm

Measuring range

pH 0…12
Temperature

0…100°C in operation
0…130°C for sterilization

Pressure resistance

From vacuum up to a process pressure of max 2.5 bar (36psi)
Reference system

Argenthal (Ag/AgCl)

Reference electrolyte

Pressurized gel electrolyte
Diaphragm

1 ceramic diaphragm

Glass shaft

Ø12 mm
Plug head

K8S, Pg 13.5 thread

RM load cells

Weight:100 kg
Dimensions: (in mm) 330 X 330

Vessel Sizing and Volume

Model

M-1000 M-5000
Total Volume (L) 1.5

8.2

Maximum Working Volume (L) for Suspension Culture

0.6-1.1 4.5-7
Depth (mm) 116

190

Height (mm)

148 320
Recommended BioNOC II Matrix volume [ml] 180

1000

Recommended amount BioNOC II Matrix in grams

10 55
Aspect Ratio

1:2.5 (for suspension) 1:3 (for microbial culture)

Specifications* of 4-in 1 VXL Hybrid Bioreactor

Adherent Cell Culture

Suspension Cell Culture Fermentation Microcarrier-Based Cell Culture
Model M-1000 M-5000 M-1000 M-5000 M-1000 M-5000 M-1000

M-5000

Vessel Material

Borosilicate Glass
Temperature Range 20ºC – 70ºC Precision: 0.1 ºC 10 ºC-70 ºC Precision: 0.1 ºC 20 ºC-70 ºC Precision: 0.1 ºC 10 ºC-70 ºC Precision: 0.1 ºC 20 ºC-70 ºC Precision: 0.1 ºC 10 ºC-70 ºC Precision: 0.1 ºC 20 ºC-70 ºC Precision: 0.1 ºC

10 ºC-70 ºC Precision: 0.1 ºC

Baffle

N/A YES YES N/A
Top Stirrer Motor

10-1200rpm

Impeller speed

25-200r pm 50-1200 rpm 50-1200 rpm 25-400 rpm
Impeller Design** Small 6-Blade Rushton Turbine 3-Pitched-Blade Turbine and 3-Marine-Blade Propeller Large 6-Blade Rushton Turbine

3-Pitched-Blade Turbine and 3-Marine-Blade Propeller

Ventilation

Ring Sparger Micro-Sparger Ring Sparger Ring Sparger
Drive Method Tide: KNF brushless motor with air pump, controlled by PID or constant voltage direct drive. Mixing: Top direct servo motor with PID/PWM control

Mixing: Top direct servo motor with PID/PWM control

Condenser

Stainless steel condenser with 0.2 um disk type or cartridge type filter
pH Range

pH 4-14 Precision: 0.01

DO Range

0-100 % Precision: 0.01%
Aeration

10L/min Precision: 2%

Emerging Time

0-100mins N/A
Submerging Time 0-100mins

N/A

Liquid Level Control

High Level Sensor Electronic Scale
Sampling liquid: sampling bottle; matrix: sample port

liquid: sampling bottle

Foaming Control

N/A YES YES YES
Control Unit

8.4” HMI

Specifications are subject to change without prior notice

III. Video

***Detailed product specification sheet: VXL™Hybrid Bioreactor.

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