Bioreactor system Esco TideXcell ®

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Model: TideXcell ®
Manufacturer: Esco VacciXcell
Status: Stocking
Guarantee: 12 months
Price: Contact

The linearly scalable Esco TideXcell ® pilot bioreactor system runs on the “Moving Tides” principle.

Esco TideXcell ® is ideal for biomass expansion of adherent cells by single-use or multiple-use technology.

Description

The pilot-scale Esco TideXcell® bioreactor system is also packed with desirable and advanced features such as the ability to measure pH and DO (Dissolved Oxygen), Siemens HMIs or PLC-based monitoring and control systems, pipelines Compressed air comes with dual HEPA and VOC (volatile organic chemicals) filters as well as other accessories.

I. Specification Esco TideXcell ® cell culture system

Tidal movements in the Esco TideXcell ® bioreactor:

 

Advantages of Esco TideXcell ®:

  • Adhesive cell scale for packing bed volumes up to 5,000L (bioequivalent of 50,000 L in suspension)
  • 100% media exchange system ideal for continuous bioprocessing
  • Separation of substrate and mixing vessel -implements dual temperature control to produce higher virus titers
  • Integrated weighing platform and in-house mixer
  • PLC-based monitoring Esco TideXcell® bioreactor system – with simple, intuitive touch screen running on Wonderware SCADA
  • Can be connected to SCADA system by DeltaV or Pcs7 . controller
  • Dual redundancy – for critical components such as PLCs and pumps provided
  • Delivers massive downscaling – and reduces costs by saving vehicles, labor, space, utility, and most importantly, eliminating cross-contamination
  • Isolation ability.
  • cGMP Standard Reference
  • PAT / IPQC.

Bioreactor system Esco TideXcell ®

Esco TideXcell ® – Applications:

  • Culture of anchorage-dependent cells with BioNOC™
  • Train series cell
  • Vaccine production
  • Production of recombinant proteins and monoclonal antibodies
  • Biosimilars and biobetters
  • Convert from 2D system to closed 3D system
  • Continuous biological treatment
  • Production of wild virus
  • Cell therapy
  • Biologic drugs for tropical diseases.

Bioreactor system Esco TideXcell ®

II. Highlights of Esco TideXcell ® pilot bioreactor system

Bioreactor system Esco TideXcell ® Bioreactor system Esco TideXcell ® Bioreactor system Esco TideXcell ® Bioreactor system Esco TideXcell ®

Homogeneous seed:

  • TideXcell ® Matrix Bed is designed to cut the area into small pieces and force the cells to flow in a radial direction instead of a vertical direction. The gradient effect in the seeding stage can be minimized.
  • A matrix cassette packed with 3D-configured carriers for optimal cell growth. Paper trays are stacked inside the matrix flask (2 L, 20 L, 100L) to uniformly granulate the cells.

esco-tidexcell

The principle of uniform sowing:
  • TideXcell ® Matrix Bed is designed to cut the area into small pieces and force the cells to flow in a radial direction instead of a vertical direction. Gradient effect in seeding stage can be minimized.

esco-tidexcell

TideXcell ® -100 packaged with matrix tray (view from above):
  • This concept is achieved by packing the matrix bed with foam tapes of smaller diameter when the matrix is packed inside.

esco-tidexcell

100% media exchange:

  • Continuous harvesting can be done in the TideXcell system due to 100% media exchange. This process is beneficial when culturing viruses to produce higher viral titers or for stem cell cultures that require switching to a different medium for differentiation.
  • Due to the separation of the platform (where cells reside) and the mixing vessel (where the mixing of cultures is taking place), the system is capable of completely collecting waste or conditioned media and feeding. in 100% fresh culture afterwards without harming the cultured cells.

Closed sampling for cell monitoring:

  • Closed system sampling can be performed in the TideXcell ® system. Each type of vessel has its own corresponding number of sampling ports.
  • A matrix cassette packed with 3D-configured carriers for optimal cell growth. Paper trays were stacked inside the matrix flask (2 L, 20 L, 100 L) to uniformly granulate the cells.

esco-tidexcell

SCADA:

  • TideXcell® based monitoring and control architecture running on WonderWare SCADA. This provides a high-level process monitoring and data collection management. This software platform will ensure process control security, will support the control strategy, and will provide a method for collecting data and remote events (alarms) for continuous process monitoring. The SCADA platform also provides functions for graphical display, alerts, trends, and historical data storage.
  • TideXcell ® is at the core of Esco Aster, a contract development manufacturing organization (CDMO) that utilizes single-use adhesive bioreactors for bioremediation needs. Esco Aster focuses on process development, commercialization of new human and animal transducing (NTD) drugs, orphan drugs, as CMO for the partner factories TideXcell ® wants. outreach in ASEAN, ANZ, Africa.

Bioreactor system Esco TideXcell ®

Esco TideXcell ® Dimensional compare:

Bioreactor system Esco TideXcell ® Bioreactor system Esco TideXcell ®

***You may be interested in GMGA’s ultra-low temperature freezer – Esco Vietnam: https://gmga.vn/en/danh-muc/process-equipment/ultra-low-temperature-freezer/

III. Specifications bioreactor system Esco TideXcell ®

TideXcell ® Product Specifications
TideXcell ® Incubation and Control Unit

Construction

External Carcass: 316 stainless steel
Dimension

125 (W) X 70 (D) X 115 (H) cm

Weight

240 kg
Electrical requirements

AC 220V 20A, 50/60 Hz, Single phase
UPS (uninterrupted power supply) width 6kVA/4.2kW should be prepared by customers

Control Hardware (2-20L)

Flexible PC-based/DAQ industrial control interface;
Solenoid valves/PID gauges/Pressure-vacuum motor
NDIR CO2 diffusion type sensor
Control Hardware (50-100 L)

Siemens HMI/PLC based control structure
Solenoid valves/PID gauges/Pressure-vacuum motor
NDIR CO2 diffusion type sensor

Control Software

Siemens PLC-based control and monitoring structure
Siemens HMI with 12.1″ touchscreen
Development environment: TIA Protal V13 SP1
Incubator

0 – 20% CO2 PID Control
+8ºC~27ºC Operating Temperature
Front view window; LED inside lighting
Emergency power-off button

Connection

CPC nickel-coated brass quick connectors
Electric connectors with locking-screw
Communication

9-pin Dsub RS-485 port : Modbus RTU protocol
2 USB Ports for import firmware / software upgrade and export trend data

Construction

264 W x 359 L X 170 H mm (10.4 x 14 x 6.7 inches)
Control Features

Simple user’s administration

Process page & Date viewer page

Data logging/Parameters logging/Events logging

Individual seed and amp

Cultivation conditions setting with default values

Automatic switch from seeding stage to cultivation stage up to 300 minutes

Automatic air refreshing mechanism

Tidal control

800 ~ 1, 800 mL/min
Gas flow rate

0.8 – 20 LPM (depends on system size)

Alkaline addition

80 mL/min at 100 rpm
Perfusion rate

80 mL/min at 100 rpm

File export

Excel (.xlx)
pH control

4~10 ± 0.1

DO control

0%~100% ± 0.5%
CO2 control

0%~10% ± 0.3%

Protection

Over pressure protection (max. 1 bar)

Liquid leaking protection

Over suction protection

Over time protection

TideXcell ® Mixing System

Magnetic Stirrer Mixing System Recirculation Thermostatic Mixing System Stir-tank Mixing System
Construction Magnetic stirrer 10 L, 20 L borosilicate glass vessel with stir bar for mixing Recirculation Mixing with magnetic driven bearing-less impeller

Stir mixing with pre-installed impeller

Electrical Requirements

Monophase 3-threads AC 220V ± 10V 5A max 50/60 Hz Single phase, AC 220v, 9A max, 50/60 Hz Three phase, 230 VAC, 50/60 Hz
Capacity 10 L and 20 L 50 L, 100 L 200 L, 500 L, 1,000 L

30 L, 50 L, 100 L, 200 L, 500 L, 1,000 L

Control

100 – 1,500 rpm stir rate RT to +45°C temperature control Pumping rate 0 – 21 LPM RT to +50ºC temperature control

80 – 1,000 rpm stir rate RT to +60ºC temperature control SIP system (sterilization in place)

Bioreactor system Esco TideXcell ®

IV. Video

***Detailed product specifications table: TideXcell ® Pilot Scale Bioreactor & TideXcell ® – 100.

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